Van de Ven Brace Halts Everton's Run at New Stadium
The Dutch defender emerged as the initial backline player to score two goals in a English top-flight game for Tottenham since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads into the net twice in opening period
The home side's defender has goal disallowed after VAR review
Pape Matar Sarr nets third in 89th minute
This loss is the Merseyside club's initial at their new ground
Micky van de Ven scored on two occasions as Tottenham extended their unbeaten run on the road in the Premier League and delivered the Toffees their first defeat at their new home.
Everton were unbeaten in their last five matches at their new ground at the dockside location, having departed their historic home behind after more than a century at the conclusion of the previous campaign.
But Spurs captain Van de Ven struck twice from set-pieces in the first half to put their impressive record at jeopardy, and they were failed to turn it around before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - headed home a final goal to seal the victory.
Jake O'Brien believed he had levelled the scores a short while after the defender's first goal, glancing a powerful header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, meanwhile, missed a handful of chances, while Vicario made a series of fine saves to ensure the London club went five away games unbeaten in the Premier League.
But the video assistant referee stepped in, instructing the match official to review the score on the screen and the referee decided that Jack Grealish and the attacker were in an illegal position and had impeded with the Spurs keeper.
This victory moves the manager's team into third place in the division, a handful of points off north London rivals and table-toppers Arsenal.
Everton remain in 14th position and are six points ahead of the relegation zone.
Tottenham analysis: The defender fulfils duties at both ends of pitch
Following a uninspiring midweek performance in the Champions League against Monaco, where they managed a only attempts on goal, the manager chose Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The new arrival was unable to make much of an impact before being replaced for the substitute after an hour on the pitch, but it emerged he wasn't needed in the end.
Centre-back Van de Ven converted into an offensive threat to be feared.
Spurs' opening strike came from a well-worked set-piece play, with the midfielder heading the ball back across the face of goal for an free Van de Ven to score.
And the captain - filling in as captain in Cristian Romero's absence - added his next goal in first-half stoppage time as he outjumped the England keeper to head home.
Van de Ven was equally outstanding in defence, partnering effectively with Kevin Danso as the duo handled superbly with the numerous deliveries thrown their way by Everton.
Toffees breakdown: Everton missing striker's instinct
The club's recent stadium had been a fortress, but it appears the novelty may have worn off slightly and supporters flocked to the exits after Sarr's third for Tottenham.
The end in Everton's winning streak at home won't be a major worry for David Moyes, but their attacking woes are.
The forward and the other striker - the Everton's pair of established centre-forwards - had scored just a single goal between them before Sunday's outing.
And they were unable to add to that miserable record on a damp and dreary night on in Liverpool.
The striker's form was epitomized when he opted to overhead kick a clear chance from close range, even with having room and time to readjust for a simpler shot that would have tested Vicario.
Barry, too, failed to influence the game after replacing Beto in the 65th minute.
It was not for a shortage of opportunity. Most of Everton's offensive moves came through Grealish and the forward, who tirelessly delivered threatening balls into the Tottenham box.
Upcoming fixtures for both teams?
The Toffees: The team travel to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on late October for their next round Carabao Cup tie against Newcastle.